On March 17, 2014, an inaugural flight from Hong Kong to Ho Chi Minh City operated by Hong Kong Airlines touched down. This Hong Kong - Ho Chi Minh route uses Airbus A320 which provides all-economy class.
The flight schedule for Ho Chi Minh City (SGN) is as follows:
| Flight no. | Route | Departure/Arrival time (local time) | Frequency |
| HX534 | Hong Kong to Ho Chi Minh City | 12:20/13:55 | Every Monday, Wednesday and Friday |
| HX535 | Ho Chi Minh City to Hong Kong | 14:55/18:30 | Every Monday, Wednesday and Friday |
This flight service makes the connection between the two destinations closer and provides passengers with wider choices for business and leisure travel between Hong Kong and Ho Chi Minh City. It also can be conveniently used as connecting flight for those who plan to travel to other nearby destinations.
